1870. Catholic families of the Jackson County area joined together and requested services of a priest from the Jesuit mission in St. Mary's, Kansas. The first Mass of the new parish community of St. Dominic was celebrated on Christmas Day.

1872. Parishioner Mrs. Catherine Bishop began peaking the interest of other parishioners to build a church. By July of that year, stone was hauled to the proposed site. Construction on the 28 x 43-frame building began in the early fall and completed in 1874.

1874. Benedictine priest Fr. Maurus Lynch, OSB, from the Abbey in Atchison, Kansas began coming to St. Dominic on the third Sunday of each month. Later that year Fr. John Begley would become the first permanent pastor.

1886. St. Dominic was a parish of 40 families and with their resident pastor, Fr. Alexander Jennings built a parish rectory. In October of that year, Fr. Jennings obtained five acres two miles west of Holton for a cemetery from the bequest of Catherine Cooney. A large wooded cross was erected and the cemetery was blessed and named Mt. Calvary.

1891. Due to the growth of the parish, the pastor added 18 feet and a sacristy to the church.

1896. A vestibule with a cupola was added to house the bell donated by Mrs. Catherine Bishop.

1914. Bishop John Ward urged the people of Holton and Mayetta to build a new church since they had out grown the one they had. The Catholic residents of Mayetta, who had for some time wanted to build their own church, and on hearing that they were to contribute $5,000 toward the new church in Holton decided to build their own church. As a result the plans for a new church in Holton were put on hold.

1918. Fr. Francis Geinitz, who over saw the construction of the new church of St. Francis Xavier in Mayetta, moved from Holton to Mayetta to become their first and only resident pastor. Fr. Patrick McIntyre was named pastor of St. Dominic.

1921. Fr. Cowell O′Neil came to Holton as pastor and renewed interest in building a new church.

1922. Property for the new church, at the corner of 5th and Ohio Aveunue, was purchased for $2,000. By spring, work began on the foundation. The foundation and the corner stone were in place by November 7. Work on the church continued through the spring of  the following year.

1923. On Christmas Day Fr. O′Neil celebrated the first Mass with the parishioners in the new church.

1924. The new church was officially dedicated on June 24, on the feast of St. John the Baptist. The new church measured 40 x 102, with a steeple that rises 110 feet into the air and is surmounted with a cross.

1929. Fr. G.F. Hart became pastor. The depression, low farm prices and hard times made the parish debt seem almost insurmountable.

1932. Fr. John Ryan was named pastor of the 50 family parish.

1945. Fr. Francis Glowacki was named pastor. During his tenure the debt on the church was paid off and the old church which had become the parish hall was remodeled. 

1950. New parish rectory was built.

1954. Fr. Leo Cooper was named pastor. During his residence, an improvement fund was established in hopes of a Catholic Grade School be opened in Holton. Property was purchased across the street from the rectory, but plans to open the grade school did not come to fruition.

1958. Fr. Anthony Lickteig was named pastor. While he was pastor, the church was repainted, a new gas furnace was installed and new stained glass windows were placed in the church completing the work begun in 1922. A second parcel of property was purchased across the street from the rectory. The house on the property would later become the home of two Benedictine Sisters of Mount St. Scholastic in Atchison who were in charge of the parish religious education program.

1964. Fr. Edward Hays was named pastor. These were the days following the Second Vatican Council. The Church was experiencing a lot of change: Mass was said in the vernacular, a second altar was added facing the people and new forms of parish administration were established.

1967. The first parish council of eight men and eight women chosen by the parishioners was convened with Gene Crannell as its first president.

1968. St. Dominic Parish adopts a sister parish: the Mission of Our Lady in Malawi, East Africa and has contributed money, ever since.

1970. St. Dominic celebrated it centennial. In preparation, the 130 families of the parish, with the guidance of Fr. Hays remodeled the interior of the church and added a new handicap entrance on the south side of the church. The parish hall was also remodeled for the occasion.

1971. Fr. William Kaufman was named pastor. He continued the improvements in the church, particularly the purchase and installation of the crucifix, and Stations of the Cross.

1979. Fr. Carl Dekat was named pastor. At that time, St. Dominic was a parish of a 150 families and was in need of a new parish hall and religious education center to replace the old parish hall which had been the first church and was 111 years old.

1983. The reality of a new parish hall and a religious education center came to fruition due to the bequest of the estate of parishioner Alice McDaniel and the improvement funds raised by the parish. In June the old parish hall was torn down and by July construction had begun on the new building. The new building would measure 82 x 42. It had a full basement with 10 classrooms for religious education.

1985. Fr. Bob Hasenkamp was named pastor. He worked diligently to create opportunities for the local Christian churches to come together to work and to pray. During his time in Holton, the mission of Our Lady of the Snows was reopened.

1991. Fr. Ron Cornish was named pastor. The St Dominic community now number 250 families. He served as pastor for 10 years.

2001. Due to the shortage of priests, St. Dominic and St. Francis Xavier was without a pastor and for several years, would be served by parochial administrators. Fr. Kyle Haden served from July 2001 to December 2001. Fr. John Fiala served from January 2002 to April 2002. Fr. Norbert Lickteig served from April 2002 to July 2002. Fr. Jon Hullinger of Nortonville served as administrator from July 2002 to July 2004, with the assistance of Fr. Robert Burger and Fr. Tom Hesse as Sacramental Ministers.

2004. In July, newly ordained priest Fr. Richard Halvorson was named Pastor of St. Dominic and its 300 families; and St. Francis Xavier and its 125 families.

2005.  In Novermber, construction began to add a vestibule-with much needed restrooms to the south side of St. Dominic church. These church-level restrooms would be the first in the church′s 83-year history.

2006. Painters from Dave Hunter Painting of Council Bluffs, Iowa arrived in early January to begin painting the interior of St. Dominic church complete with intricate gold-leaf stencils. There were also minor renovations done to the interior of the church with included the installation of new red oak cushioned pews. The renovations were complete in June of the following year.

2008. Remodeling project for the rectory was started, the first changes to the rectory since its construction in 1950. The project was completed in the spring of 2009.

2009.  In July, Fr. Francis Bakyour, on loan from the Diocese of Damongo in Ghana, Africa, was appointed parochial administrator of St. Dominic and St. Francis Xavier. After a month, he needed to return to his homeland. Fr. Bill Bruning took over as parochial administrator in September while remaining pastor of Blessed Mother Theresa parish in Topeka. Fr. Chris Rossman served as an associate administrator.

2010. In July, Fr. Chris Rossman was appointed pastor of St. Dominic and St. Francis Xavier. 

2015. In July, Fr. Marianand Mendem was appointed pastor of St. Dominic and St. Francis Xavier.

2018. In July, Fr. Jonathan Dizon was appointed pastor of St. Dominic and St. Francis Xavier.